ULTRASOUND OF SINGLE
UMBILICAL ARTERY (1-14) |
The sonographic diagnosis of SUA can be made as early as 12 weeks gestation, although the highest rates of detection are at 17 to 35 weeks (12).
Evaluation of the umbilical arteries can be done by looking at a free portion of the cord, either longitudinally or in cross-section, or by using color Doppler in the area of the fetal abdominal cord insertion site to identify the umbilical arteries as they course on either side of the fetal bladder. It is by the latter method that the side of the missing umbilical artery can be determined.
Some authors have suggested that visualization of the vessels around the fetal bladder may not be as accurate as looking at a free loop of cord (12,13), primarily because it seems to increase the false-positive rate.
Using a transverse view of a free loop of the umbilical cord to make the diagnosis of SUA, transabdominal sonography was reported in one series to have an 85% sensitivity, a 99.7% specificity, an 85% positive predictive value, and a 99.7% negative predictive value for the detection of a two-vessel cord (12). The false-positive rate in this series was only 0.03%; in another series that used both a cross-sectional image of the umbilical cord and visualization of the two vessels coursing around the bladder, the false-positive rate was much higher (14%) (12-14).
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GRAY-SCALE IMAGES |
Single umbilical artery.
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Single umbilical artery
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Two and three vessel cord in the same fetus at slightly different
levels. |
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COLOR DOPPLER IMAGING OF THE CORD |
COLOR DOPPLER IMAGING OF THE FETAL PELVIS |
Single umbilical artery around the bladder |
Normal – two umbilical arteries around the bladder |
Video clip of single umbilical artery
–differentiation from the common iliac artery |
PULSED DOPPLER |
Doppler flow indices in normal and small for gestational age fetuses with SUA are not significantly different from normal fetuses (4). This has been attributed to compensatory arterial dilatation in the single umbilical artery, which acts to prevent growth retardation.
DIAMETER OF THE UMBILICAL CORD |
The above studies assume a compensatory increase in the size of the
remaining umbilical artery. Brohnshtein and Zimmer
(7) did not confirm these observations. The differences may be due to the
technical limitations that are inherent when accurately trying to measure cord
vessels (6):
De Catte (4) demonstrates that measurements taken when the arterial wall lining on both sides is brightly echogenic means the ultrasound beam are perpendicular to the arterial wall. If the vessel was truly circular only a small echogenic spot should be present. A large echogenic line means the vessel is elliptical at some points.
Measurements obtained at
different states of fetal activity may demonstrate differences in blood flow
and vessel diameter.
Gill and colleagues (11) - 10% variation in umbilical vein diameter and 20%
difference in blood flow on repeated measurements.
It is important to distinguish between SUA and fusion of the two umbilical arteries. Umbilical artery fusion may occur completely or intermittently along the length of the umbilical cord (16). Fusion of the two arteries may be mistaken for SUA if multiple portions of the cord are not examined. The frequency of fusion of the two umbilical arteries was found to be 3.1% in one study of placentas from 702 consecutive deliveries (17). The low frequency of SUA in this series (0.2%) may reflect the true incidence of SUA in the general population when fusion of the two umbilical arteries has been excluded. It is important to distinguish between fusion of the two umbilical arteries and SUA whenever possible, because there is no evidence that fusion of the two umbilical arteries is associated with adverse perinatal outcomes (17,18). If both two- and three-vessel cords are identified, the patient should be considered to have a normal three-vessel umbilical cord (19). Like SUA, fusion of the two umbilical arteries has been associated with increased rates of marginal (18.1%) and velamentous (4.5%) cord insertions (17) as compared with singletons.
Sonographic Approach:
Because the finding of SUA carries with it a substantially increased risk of congenital abnormalities and aneuploidy, the finding of SUA on a second-trimester ultrasound should prompt an immediate detailed ultrasound examination to rule out any associated abnormalities. Referral to an experienced center should be done whenever necessary.
Fetal echocardiography should be obtained:
· In one series, 5% of fetuses referred for fetal echo with presumed isolated SUA had abnormal findings (15).
· In another series, however, fetal echo did not add any diagnostic information in fetuses with SUA when the normal four-chamber and outflow tract views of the heart had been obtained satisfactorily (14).
Invasive testing for chromosome analysis should be recommended if any associated abnormalities are identified on sonogram, including structural anomalies, oligohydramnios, polyhydramnios, and IUGR.
In the absence of associated anomalies, invasive testing is not warranted, because there is no increased risk of aneuploidy.
Patients should be counseled, however, that even when SUA is apparently isolated 7% of fetuses in one series had structural anomalies diagnosed postnatally, which if diagnosed prenatally would have resulted in a recommendation for invasive testing (20).
Serial growth scans are warranted, because SUA has been associated with increased rates of IUGR. Antenatal testing is recommended in the setting of IUGR or oligohydramnios. Doppler studies should also be used to assess the status of an IUGR fetus. Despite there being only one umbilical artery, it has been shown that longitudinal changes in Doppler flow indices in normal and small-for-gestational-age fetuses with SUA have comparable reference ranges to fetuses with three-vessel cords (4). A large prospective series of umbilical artery Doppler velocimetry in pregnancies with a SUA found that abnormal Doppler findings were associated significantly with IUGR, presence of complex malformations, aneuploidy, preterm delivery, and perinatal mortality. Conversely, normal umbilical artery Doppler indicates a relatively good prognosis, in particular a low-risk of fetal aneuploidy or perinatal mortality (21). Unlike umbilical artery blood flow, the ductus venosus blood flow pattern seems to be different in SUA fetuses when compared with that of fetuses with three-vessel cords (22). Future studies are needed to evaluate individual Doppler parameters in the fetus with SUA before they can be used routinely in these fetuses.
REFERENCES |